On the lookout for an outstanding best systemic enzymes? Our expert team has combed through the market, carefully selecting and testing the best products available. We’ve put each best systemic enzymes through a series of both practical and analytical tests to provide a comprehensive understanding of their capabilities and limitations.
Our detailed reviews delve into the critical components of each product. We assess the main features, overall performance, and cost-to-benefit ratio, aiming to offer you a well-rounded and unbiased perspective. Our selection focuses on crucial factors like Performance, Simplicity of Use, and Value. We cater to a range of individual preferences and financial situations, aiming to help you find the best systemic enzymes that surpasses your expectations.
Editor’s Note: In March 2024, this review was updated with the latest market developments and additional product options, ensuring that our recommendations remain relevant and encompassing for your decision-making process.
Top Products for best systemic enzymes
1. Pure Encapsulations Systemic Enzyme Complex | Supplement to Support Muscle, Joint, Cartilage, and Connective Tissue Health* | 180 Capsules
Key Features:
- Muscular Health: Systemic Enzyme Complex is formulated to support the overall health of the musculoskeletal system.*
- Muscle Comfort: Supports a healthy response to temporary muscle soreness and temporary joint discomfort associated with exercise.*
- Joint & Cartilage Health: Supports healthy connective tissue, as well as joint and cartilage health.*
- Pure Quality: Our supplements are made with only premium ingredients sourced from trusted suppliers and guided by our nutritional experts, then carefully manufactured and tested to verify their potency and purity.
- Pure Difference: What makes us different isn’t just our process or what goes into our supplements — what we leave out matters, too. Pure Encapsulations products are FREE FROM wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.
Buy Now From Amazon – $77.60 ($0.43 / Count)
2. Doctor’s Best Proteolytic enzymes, Digestion, Muscle, Joint, Non-GMO, Gluten Free, Vegetarian, 90 Veggie Caps
Key Features:
- Doctor’s Best Proteolytic Enzymes is a potent formulation containing a broad spectrum of proteolytic enzymes (proteases).
- Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery
- Proteolytic enzymes function in the body to digest and break down proteins into their amino acid components
- Proteolytic Enzymes Provide Support for Muscle, Joint, and Overall Tissue Health
- Proteolytic Enzymes will appear in clear encapsulation, with no enteric coating and the potency, safety and quality of this product will remain the same
- During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers’ recommendations, when provided.
Buy Now From Amazon – $28.86 ($0.32 / Count)
3. HCP Formulas – Fibrenza – Systemic Enzyme Complex with Fibrinolytic & Proteolytic Enzymes – Fibrin Defense & Cardiovascular Support – Vegetarian – Dietary Supplement – 60 Caps
Key Features:
- FIBRENZA SUPPLEMENT: An advanced blend of 13 powerful systemic enzymes! HCP Formulas’ Fibrenza is a natural systemic enzyme complex. Formulated with fibrinolytic & proteolytic enzymes, Fibrenza supports the body’s ability to dissolve fibrin and cleanse the body of impurities for maximum body-wide benefits in a reliable, time-released capsule.
- CARDIOVASCULAR SUPPORT: Aging lowers your body’s ability to produce sufficient levels of enzymes, often leading to build-up of fibrin. Fibrenza harnesses potent systemic enzymes that break down proteins, toxins, and other cellular debris, such as Serrapeptase and Nattokinase—promoting powerful defense for a healthy cardiovascular system.
- ANTIOXIDANT: Enzymes possess profound antioxidant properties. These properties are the foundation of anti-aging and detoxification protocols, Superoxide Dismutase helps break down potentially harmful oxygen molecules in cells that can cause tissue damage for better overall well-being.
- SUPERIOR DELIVERY: Fibrenza utilizes a technologically advanced capsule without phthalates. Unlike enteric coatings, AcidDefenz capsules use a non-GMO vegetable cellulose barrier to provide for a time-release for more consistent enzyme absorption and effectiveness.
- PREMIUM INGREDIENTS: HCP Formulas specializes in ultra-premium nutraceutical supplements to better support your health. We source only the highest-grade Non-GMO ingredients that are vegetarian and free of gluten, dairy, wheat, yeast, and shellfish. Fibrenza contains NO Phthalates, Talc, or artificial colors or flavors and is proudly manufactured in the USA in GMP registered facilities.
Buy Now From Amazon – $39.99 ($0.67 / Count)
4. VITÄLZYM Proteolytic Systemic Enzymes Liquid Gel Capsules with Serrapeptase, Immune and Joint Support, Natural Ache Relief Plus Fertility Supplement (360 Capsules)
Key Features:
- Enteric Coated Advanced Delivery Method: Vitalzym high potency gel caps are unlike any tablet or powder based enzyme product available on the market today. Our formula contains no gluten, yeast or dairy and is designed to ensure maximum absorption into the bloodstream where it is then dispersed via your circulatory system throughout your body
- Ingredients: Vitalzym Extra Strength premium softgels are the original, all-natural, vegetarian multi enzyme complex. Vitalzym was designed using a scientific research process to identify nature’s miracle ingredients that include Serrapeptase, Bromelain, Papain, Rutin, Amylase, Protease, Lipase and Amla Extract
- Protect Your Health: Living well in modern times can be stressful and a source of pain at times. Vitalzym contains the most effective, purified vegan-based enzyme blend to promote healing, human bodily functions and leave you feeling clear and fresh
- Small, Easy To Swallow Gel Caps: Our advanced encapsulations deliver reliable results that offer pure, potent enzymes with reliable consistency and unrivaled absorption rates. Due to the highly effective delivery rate most people need a smaller dosage, and less doses per day
- Made In Japan: Created by a team of international scientists, Vitalzym works best when combined with exercise, proper fluid intake, and a healthy diet. It is important to be mindful of all aspects of your health. When used properly, Vitalzym can assist with cardio, lung, and immune response as well as provide joint, inflammation support and much more
Buy Now From Amazon – $149.00 ($0.41 / Count)
5. Excellacor | Proteolytic Systemic Enzymes Formula | with Acid-Resistant Serrapeptase | Total Body Support | 90 Vegetarian Capsules
Key Features:
- ADVANCED SYSTEMIC ENZYME FORMULA: a potent blend of enzymes, including acid-resistant serrapeptase & proteases, and herbs that synergistically support the body’s natural response to inflammation and joint function; used for more than a decade by thousands of people as a daily dietary supplement.*
- RANGE OF USE: Supports the body’s natural response to inflammation including fatigued muscles and joint function, healthy blood circulation, and healthy fibrin metabolism.*
- ACHIEVE OPTIMAL HEALTH: Elimination of potential waste substances from the body is a crucial step in metabolic processes for optimal health. Excellacor improves the body’s ability to rid of these wastes and restore normal balance.*
- QUALITY ASSURED: All products by AST Enzymes are manufactured in the USA, free of animal derivatives, dairy, yeast, fish or shellfish, peanuts, and tree nuts.
Buy Now From Amazon – $19.99 ($0.22 / Count)
6. Nature’s Way Mega-Zyme Systemic Enzymes, Relieves Occasional Muscle Soreness and Discomfort*, Pancreatic Enzymes, Digestive Support*, Reduces Occasional Digestive Discomfort*, 200 Tablets
Key Features:
- Nature’s Way Mega-Zyme is a blend of systemic and pancreatic enzymes for digestive support.*
- When taken between meals, formulated to help relieve occasional muscle soreness and discomfort due to overexertion and exercise.*
- When taken with food, supports digestion and helps reduce occasional gas and bloating.*
- Contains egg and milk. No artificial colors.
- At Nature’s Way, we believe nature is the ultimate problem solver. For over 50 years, we have looked to the natural world for inspiration. Our quality vitamins and supplements are formulated to help you find your way to wellness.
Buy Now From Amazon – $27.74 ($0.14 / Count)
7. Carlyle Proteolytic Enzymes | 300 Capsules | Systemic Broad Spectrum Supplement | Vegetarian, Non-GMO & Gluten Free Formula
Key Features:
- PROTEOLYTIC ENZYMES: Can be found naturally in certain foods like papaya and pineapple
- BROAD SPECTRUM: Features an Advanced Enzyme Complex with Premium Turmeric Curcumin for added support
- ROOTED IN WELLNESS: Carlyle provides premium, honest supplements in your pursuit to healthy living
- CARLYLE MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
- NATURALLY FREE OF: Gluten, Wheat, Yeast, Milk, Artificial Flavor, Sweetener, Preservatives & Non-GMO
Buy Now From Amazon – $19.99 ($0.07 / Count)
8. VITÄLZYM Original Proteolytic Systemic Digestive Enzyme Formula Serrapeptase Source | Immune and Joint Support Increase Blood Flow Cardio Function | Healthy Men Women (450 Capsules)
Key Features:
- American Made, Essential for Health, Plant Based: Not All Complete Digestive System Enzyme Products Are Made The Same – Pay For True Quality & You Will Not Be Disappointed. World Nutrition is a pioneer of complementary systemic enzymes. In 2001 we introduced the original Vitalzym pill as a hybrid formula that offers both systemic & digestive benefits to provide total body support. It quickly became the best-selling systemic enzyme in the world and sold over $10M in the first 3 years alone
- The Best Vegetarian Digestion Supplement & Remedy: Our Premium Strength Super Gut Defense Formula contains everything you need for full-body support: Protease, Serrapeptase, Papain, Bromelain, Amylase, Lipase, Rutin, & Amla. Each powerful ingredient is derived from natural, vegetarian sources. Most competitors use enzymes harvested from pigs & cows after slaughter. These enzymes are low-quality & strength, requiring a much higher dose as they’re less effective against targeted mediators
- Advanced, Broad Spectrum Caps Promote Wellness: Our complex extract provides the optimal potency level of proteolytic enzymes that may assist with IBS, gas, inflammation, regulating your immune system, removing excess plaque & fibrin (fibrous tissue), & support the return of blood volume & flow. Vitälzym capsules are formulated to support health in the following systems: cognitive/mental, upper respiratory, cardiovascular, gastrointestinal, reproductive, joints, connective tissue, & skin
- Fast Response, Organic, Calms Indigestion & Assists With IBS, Gas, Bloating: Regain bowel comfort with our perfect synergistic blend of systemic and digestive enzymes. It starts in the stomach & helps the body to break down food and absorb nutrients. After helping increase digestive abilities, the systemic enzymes take action in the bloodstream, moving throughout your entire body. This unique combination can help to improve your bodily processes and regain your quality of life
- Formulated for Active Vitality Enhancement Plus Recovery: High-quality pure powder filled capsules that break down in your stomach provide digestive support with every dose. Some serrapeptase survives the acidic environment of the stomach and a dosage is released in the small intestine, allowing it to be absorbed into your bloodstream and distributed throughout your whole body. Our customers have reported increased energy, stamina, and recovery from intense exercise
Buy Now From Amazon – $120.00 ($0.27 / Count)
9. Integrative Therapeutics Bio-Zyme- Systemic Enzymes* – Full-Strength Pancreatic Enzyme Complex for Digestive Support* – 200 Tablets
Key Features:
- Systemic enzyme providing pancreatic enzymes.*
- Bio-Zyme is formulated with systemic enzymes for digestive support and relief of occasional muscle soreness due to overexertion.*
- With undiluted pancreatic enzymes for digestive support.*
- No artificial colors. Contains milk and sulfites.
- Integrative Therapeutics supplements are trusted by physicians and backed by science. Every product is held to our high standards and rigorously tested to empower you on your wellness journey. Because confidence is healthy.
Buy Now From Amazon – $42.00 ($0.21 / Count)
10. Serrapeptase Enzymes Capsules | Up to 2 Month Supply | Enzyme Supplement for High Potency Sinus Relief Pills for Allergy Support | Tissue Health and Cellular Health | Vegan | Gluten Free | 60 Count
Key Features:
- Serrapeptase Systemic Enzymes: This proprietary blend of enteric-coated Serrapeptase (also known as Serratiopeptidase) and a Protease blend is combined with enzyme enhancing vitamins and minerals to support your overall health. Encapsulated in pine-based vegan capsules, you can easily incorporate these into your routine.
- Multiple Benefits: Serrapeptase may help to support the body’s circulatory system, healthy tissue homeostasis, and the body’s natural inflammation process. This powerful enzyme blend may support cellular, tissue, and systemic health, while promoting healthy immune activity and aiding your body in maintaining normal microbial balance.
- Advanced Enzyme Complex: 120,000 SPU Serrapeptase in each capsule. Sometimes referred to as a “super enzyme,” Serrapeptase has been shown to have an effect on the movement of immune cells while the Protease blend works at normal cellular detoxification to efficiently digest all types of proteins. Pairing these enzymes with cofactor vitamins and minerals helps your body use the enzymes faster and more efficiently.
- Easy Efficient Absorption: Formulated to be taken systemically, not digestively. It’s best to take on an empty stomach, allowing enzymes to support your body rather than digest your food. Adults take 1 capsule, up to 2 times daily or as recommended by physician or healthcare professional. For best results, take on an empty stomach with a large glass of water, 30-60 minutes before or 2 hours after a meal.
- For Most Lifestyles: MaryRuth’s Serrapeptase Systemic Enzymes are Non-GMO & Vegan. Dairy Free, Nut Free, Gluten & Wheat Free, Soy Free, Nightshade Free, Sugar Free. This product CONTAINS Maltodextrin: which is corn-derived.
Buy Now From Amazon – $24.95 ($0.42 / Count)
Essential Buyer’s Guide for Selecting the Perfect best systemic enzymes
Identify Your Requirements
Pinpoint what you specifically need from the best systemic enzymes. Understand the features and functionalities that are most critical for your use-case to narrow down your choices.
Inspect Product Quality
Always prioritize the quality of the best systemic enzymes. High-quality items tend to last longer and provide better performance. Look for products with strong materials, good build quality, and positive user feedback.
Assess Brand Reputation
The brand’s history can tell you a lot about the quality and reliability of the best systemic enzymes. A reputable brand usually guarantees a certain level of quality and customer service.
Vendor Credibility
Consider the credibility of the seller or manufacturer. A reputable vendor or manufacturer often correlates with better customer service and product reliability.
User Reviews and Ratings
Take the time to read through user reviews and ratings. They offer valuable insights into how the best systemic enzymes performs in real-world scenarios and can highlight any potential issues.
Longevity and Maintenance
Consider how long the best systemic enzymes lasts under normal use. A product that requires less maintenance and is more durable is typically a better investment.
Usability and Convenience
Ensure the best systemic enzymes is easy to use and fits comfortably into your routine or lifestyle. User-friendly products enhance your experience and are more likely to satisfy your needs.
Compare Price to Value
Evaluate if the best systemic enzymes’s price is reflective of its value. Sometimes paying a little extra upfront can save you money in the long run due to better quality or features.
Product Availability
Check the availability of the best systemic enzymes. Products that are easily accessible tend to have better after-sales support and availability of parts or accessories.
Comprehensive Comparison
Compare different best systemic enzymes products against each other. Look at each option’s features, benefits, and drawbacks to make an informed decision.
Warranty and After-Sales Support
A solid warranty and reliable customer support can greatly enhance your experience with the best systemic enzymes. These factors can also provide peace of mind and save costs in the future.
Stay Updated
The market is always evolving. Keep an eye on new releases and developments to ensure you choose a best systemic enzymes that remains relevant and up to date.
Make Your Final Choice
After thorough consideration, choose the best systemic enzymes that best meets your criteria and expectations, balancing all factors like quality, usability, and cost.
Our reviews and guides are meticulously curated to assist you in navigating the selection process, helping you make a choice that’s both satisfying and well-informed.